Chipal Chelating Resins in Chromatogpaphy of Optical Isomers

The ways of binding optically active ligands, mainly of the amino acid type, to cross—linked polymers of styrene, acrylamide or glycidylmethacrylate are reviewed. When coordina— ted to transition metal ions, these polymers display a high discriminating ability in sorption of optical isomers of corn— pounds capable of forming mixed—ligand complexes. The kinetic performance of the ligand—exchanging sorbents is considerably improved by applying a rnacronet isoporous polystyrene matrix. A mechanism of chiral recognition of amino acid enantiorners is discussed, which is based on structural studies of low-molecular-weight ligands and complexes simulating the active sites and the inixed-ligand sorption complexes in the resin phase.